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Implications for Gene Therapy-Limiting Expression of IL-2Rγ(c) Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance
X-linked SCID patients are deficient in functional IL-2Rγ(c) leading to the loss of IL-2/IL-4/IL-7/IL-9/IL-15/IL-21 signaling and a lack of NK and mature T cells. Patients treated with IL-2Rγ(c) gene therapy have T cells develop; however, their NK cell numbers remain low, suggesting antiviral respon...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6417809/ https://ncbi.nlm.nih.gov/pubmed/20592278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903528 |
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