IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging

Clinical and experimental studies show that age-related decline in circulating insulin-like growth factor-1 (IGF-1) levels promotes the pathogenesis of intracerebral hemorrhages, which critically contribute to the development of vascular cognitive impairment and disability in older adults. Yet, the...

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Detalhes bibliográficos
Publicado no:J Gerontol A Biol Sci Med Sci
Main Authors: Fulop, Gabor A, Ramirez-Perez, Francisco I, Kiss, Tamas, Tarantini, Stefano, Valcarcel Ares, Marta Noa, Toth, Peter, Yabluchanskiy, Andriy, Conley, Shannon M, Ballabh, Praveen, Martinez-Lemus, Luis A, Ungvari, Zoltan, Csiszar, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
The Journal of Gerontology: Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417448/
https://ncbi.nlm.nih.gov/pubmed/29931048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gly144
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