Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies. However, it also promotes accelerated senescence in healthy tissues and leads to progressive cognitive dysfunction in up to 50% of tumor patients s...

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Publicado en:GeroScience
Main Authors: Ungvari, Zoltan, Tarantini, Stefano, Hertelendy, Peter, Valcarcel-Ares, M. Noa, Fülöp, Gabor A., Logan, Sreemathi, Kiss, Tamas, Farkas, Eszter, Csiszar, Anna, Yabluchanskiy, Andriy
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352588/
https://ncbi.nlm.nih.gov/pubmed/28299642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-017-9964-z
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