Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies. However, it also promotes accelerated senescence in healthy tissues and leads to progressive cognitive dysfunction in up to 50% of tumor patients s...

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Опубликовано в: :GeroScience
Главные авторы: Ungvari, Zoltan, Tarantini, Stefano, Hertelendy, Peter, Valcarcel-Ares, M. Noa, Fülöp, Gabor A., Logan, Sreemathi, Kiss, Tamas, Farkas, Eszter, Csiszar, Anna, Yabluchanskiy, Andriy
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352588/
https://ncbi.nlm.nih.gov/pubmed/28299642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-017-9964-z
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