An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

BACKGROUND: Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce. INSPIRE is a phase 2 basket study to evaluate the genomic and immune landscap...

Full description

Saved in:
Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Clouthier, Derek L., Lien, Scott C., Yang, S. Y. Cindy, Nguyen, Linh T., Manem, Venkata S. K., Gray, Diana, Ryczko, Michael, Razak, Albiruni R. A., Lewin, Jeremy, Lheureux, Stephanie, Colombo, Ilaria, Bedard, Philippe L., Cescon, David, Spreafico, Anna, Butler, Marcus O., Hansen, Aaron R., Jang, Raymond W., Ghai, Sangeet, Weinreb, Ilan, Sotov, Valentin, Gadalla, Ramy, Noamani, Babak, Guo, Mengdi, Elston, Sawako, Giesler, Amanda, Hakgor, Sevan, Jiang, Haiyan, McGaha, Tracy, Brooks, David G., Haibe-Kains, Benjamin, Pugh, Trevor J., Ohashi, Pamela S., Siu, Lillian L.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417194/
https://ncbi.nlm.nih.gov/pubmed/30867072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0541-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items