An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

BACKGROUND: Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce. INSPIRE is a phase 2 basket study to evaluate the genomic and immune landscap...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Clouthier, Derek L., Lien, Scott C., Yang, S. Y. Cindy, Nguyen, Linh T., Manem, Venkata S. K., Gray, Diana, Ryczko, Michael, Razak, Albiruni R. A., Lewin, Jeremy, Lheureux, Stephanie, Colombo, Ilaria, Bedard, Philippe L., Cescon, David, Spreafico, Anna, Butler, Marcus O., Hansen, Aaron R., Jang, Raymond W., Ghai, Sangeet, Weinreb, Ilan, Sotov, Valentin, Gadalla, Ramy, Noamani, Babak, Guo, Mengdi, Elston, Sawako, Giesler, Amanda, Hakgor, Sevan, Jiang, Haiyan, McGaha, Tracy, Brooks, David G., Haibe-Kains, Benjamin, Pugh, Trevor J., Ohashi, Pamela S., Siu, Lillian L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417194/
https://ncbi.nlm.nih.gov/pubmed/30867072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0541-0
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