The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors

CXCL8 is a chemokine secreted by normal and thyroid cancer cells with proven tumor-promoting effects. The presence of BRAFV600E mutation is associated with a more aggressive clinical behavior and increased ability to secrete CXCL8 by papillary-thyroid-cancer cells. Aim of this study was to test the...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Coperchini, Francesca, Croce, Laura, Denegri, Marco, Awwad, Oriana, Ngnitejeu, Samuel Tata, Muzza, Marina, Capelli, Valentina, Latrofa, Francesco, Persani, Luca, Chiovato, Luca, Rotondi, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416278/
https://ncbi.nlm.nih.gov/pubmed/30867499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40818-w
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