Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading to synapse dysfunction in Alzheimer’s disease (AD). In the present study, we report that the release probability (Pr) at the synapse between the Schaffer collateral (SC) and CA1 pyramida...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Autores principales: He, Yang, Wei, Mengdi, Wu, Yan, Qin, Huaping, Li, Weinan, Ma, Xiaolin, Cheng, Jingjing, Ren, Jinshuai, Shen, Ye, Chen, Zhong, Sun, Binggui, Huang, Fu-De, Shen, Yi, Zhou, Yu-Dong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416269/
https://ncbi.nlm.nih.gov/pubmed/30867420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09114-z
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares