Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides

Antisense oligonucleotides (ASOs) have the potential to revolutionize medicine due to their ability to manipulate gene function for therapeutic purposes. ASOs are chemically modified and/or incorporated within nanoparticles to enhance their stability and cellular uptake, however, a major challenge i...

詳細記述

保存先:
書誌詳細
出版年:Nano Lett
主要な著者: Ezzat, Kariem, Aoki, Yoshitsugu, Koo, Taeyoung, McClorey, Graham, Benner, Leif, Coenen-Stass, Anna, O'Donovan, Liz, Lehto, Taavi, Garcia-Guerra, Antonio, Nordin, Joel, Saleh, Amer F., Behlke, Mark, Morris, John, Goyenvalle, Aurelie, Dugovic, Branislav, Leumann, Christian, Gordon, Siamon, Gait, Michael J., El–Andaloussi, Samir, Wood, Matthew JA
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415796/
https://ncbi.nlm.nih.gov/pubmed/26042553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b00490
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