Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides

Antisense oligonucleotides (ASOs) have the potential to revolutionize medicine due to their ability to manipulate gene function for therapeutic purposes. ASOs are chemically modified and/or incorporated within nanoparticles to enhance their stability and cellular uptake, however, a major challenge i...

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Veröffentlicht in:Nano Lett
Hauptverfasser: Ezzat, Kariem, Aoki, Yoshitsugu, Koo, Taeyoung, McClorey, Graham, Benner, Leif, Coenen-Stass, Anna, O'Donovan, Liz, Lehto, Taavi, Garcia-Guerra, Antonio, Nordin, Joel, Saleh, Amer F., Behlke, Mark, Morris, John, Goyenvalle, Aurelie, Dugovic, Branislav, Leumann, Christian, Gordon, Siamon, Gait, Michael J., El–Andaloussi, Samir, Wood, Matthew JA
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415796/
https://ncbi.nlm.nih.gov/pubmed/26042553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b00490
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