Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides

Antisense oligonucleotides (ASOs) have the potential to revolutionize medicine due to their ability to manipulate gene function for therapeutic purposes. ASOs are chemically modified and/or incorporated within nanoparticles to enhance their stability and cellular uptake, however, a major challenge i...

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Detalhes bibliográficos
Publicado no:Nano Lett
Main Authors: Ezzat, Kariem, Aoki, Yoshitsugu, Koo, Taeyoung, McClorey, Graham, Benner, Leif, Coenen-Stass, Anna, O'Donovan, Liz, Lehto, Taavi, Garcia-Guerra, Antonio, Nordin, Joel, Saleh, Amer F., Behlke, Mark, Morris, John, Goyenvalle, Aurelie, Dugovic, Branislav, Leumann, Christian, Gordon, Siamon, Gait, Michael J., El–Andaloussi, Samir, Wood, Matthew JA
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415796/
https://ncbi.nlm.nih.gov/pubmed/26042553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b00490
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