The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis

The LIM-homeodomain (LIM-HD) transcription factor Islet-1 (Isl1) interacts with the LIM domain-binding protein 1 (Ldb1) coregulator to control expression of key pancreatic β-cell genes. However, Ldb1 also has Isl1-independent effects, supporting that another LIM-HD factor interacts with Ldb1 to impa...

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Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Bethea, Maigen, Liu, Yanping, Wade, Alexa K., Mullen, Rachel, Gupta, Rajesh, Gelfanov, Vasily, DiMarchi, Richard, Bhatnagar, Sushant, Behringer, Richard, Habegger, Kirk M., Hunter, Chad S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415717/
https://ncbi.nlm.nih.gov/pubmed/30620636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00235.2018
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