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False signals induced by single-cell imputation

Background: Single-cell RNA-seq is a powerful tool for measuring gene expression at the resolution of individual cells.  A challenge in the analysis of this data is the large amount of zero values, representing either missing data or no expression. Several imputation approaches have been proposed to...

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Detalhes bibliográficos
Publicado no:F1000Res
Main Authors: Andrews, Tallulah S., Hemberg, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415334/
https://ncbi.nlm.nih.gov/pubmed/30906525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.16613.2
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