Quantification of mRNA in single cells and modelling of RT-qPCR induced noise

BACKGROUND: Gene expression has a strong stochastic element resulting in highly variable mRNA levels between individual cells, even in a seemingly homogeneous cell population. Access to fundamental information about cellular mechanisms, such as correlated gene expression, motivates measurements of m...

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Main Authors: Bengtsson, Martin, Hemberg, Martin, Rorsman, Patrik, Ståhlberg, Anders
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483285/
https://ncbi.nlm.nih.gov/pubmed/18631407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-63
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