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Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity

The influenza virus protein PA-X modulates the host immune responses and viral pathogenicity through suppression of host protein expression. The endonuclease active site in the N-terminal region, the basic amino acid cluster in the C-terminal PA-X-specific region, and N-terminal acetylation of PA-X...

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Foilsithe in:Front Microbiol
Main Authors: Oishi, Kohei, Yamayoshi, Seiya, Kawaoka, Yoshihiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414799/
https://ncbi.nlm.nih.gov/pubmed/30894843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00432
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