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Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast

The influenza A virus protein PA-X comprises an N-terminal PA region and a C-terminal PA-X-specific region. PA-X suppresses host gene expression, termed shutoff, via mRNA cleavage. Although the endonuclease active site in the N-terminal PA region of PA-X and basic amino acids in the C-terminal PA-X-...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Oishi, Kohei, Yamayoshi, Seiya, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296753/
https://ncbi.nlm.nih.gov/pubmed/29331676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.01.004
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