Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket

HIV-1 capsid protein (CA) plays critical roles in both early and late stages of the viral replication cycle. Mutagenesis and structural experiments have revealed that capsid core stability significantly affects uncoating and initiation of reverse transcription in host cells. This has led to efforts...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:mBio
Päätekijät: Craveur, Pierrick, Gres, Anna T., Kirby, Karen A., Liu, Dandan, Hammond, John A., Deng, Yisong, Forli, Stefano, Goodsell, David S., Williamson, James R., Sarafianos, Stefan G., Olson, Arthur J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2019
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414707/
https://ncbi.nlm.nih.gov/pubmed/30862755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02858-18
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