Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket

HIV-1 capsid protein (CA) plays critical roles in both early and late stages of the viral replication cycle. Mutagenesis and structural experiments have revealed that capsid core stability significantly affects uncoating and initiation of reverse transcription in host cells. This has led to efforts...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Craveur, Pierrick, Gres, Anna T., Kirby, Karen A., Liu, Dandan, Hammond, John A., Deng, Yisong, Forli, Stefano, Goodsell, David S., Williamson, James R., Sarafianos, Stefan G., Olson, Arthur J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414707/
https://ncbi.nlm.nih.gov/pubmed/30862755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02858-18
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