Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methylene-tetrahydrofolate (THF) to 5-methyl-THF, thereby committing one-carbon units to the methionine cycle. While MTHFR has long been known to be allosterically inhibited by S-adenosylmethionine (SAM), only...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Zheng, Yuxiang, Ramsamooj, Shivan, Li, Qian, Johnson, Jared L., Yaron, Tomer M., Sharra, Klaus, Cantley, Lewis C.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414673/
https://ncbi.nlm.nih.gov/pubmed/30862944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40950-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items