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Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methylene-tetrahydrofolate (THF) to 5-methyl-THF, thereby committing one-carbon units to the methionine cycle. While MTHFR has long been known to be allosterically inhibited by S-adenosylmethionine (SAM), only...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6414673/ https://ncbi.nlm.nih.gov/pubmed/30862944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40950-7 |
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