Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer’s disease (AD) may arise from altered cholesterol metabolism, although the molecular pathways that may link cholesterol to AD phenotypes are only partially understood. Here, we perform a phenotypic screen for...

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Vydáno v:Cell Stem Cell
Hlavní autoři: van der Kant, Rik, Langness, Vanessa F., Herrera, Cheryl M., Williams, Daniel A., Fong, Lauren K., Leestemaker, Yves, Steenvoorden, Evelyne, Rynearson, Kevin D., Brouwers, Jos F., Helms, J. Bernd, Ovaa, Huib, Giera, Martin, Wagner, Steven L., Bang, Anne G., Goldstein, Lawrence S.B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414424/
https://ncbi.nlm.nih.gov/pubmed/30686764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.12.013
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