Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis

BACKGROUND: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease. However, our recent studies on the skeletal m...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Pigna, Eva, Simonazzi, Elena, Sanna, Krizia, Bernadzki, Krzysztof Marian, Proszynski, Tomek, Heil, Constantin, Palacios, Daniela, Adamo, Sergio, Moresi, Viviana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414308/
https://ncbi.nlm.nih.gov/pubmed/30713114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.038
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