Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy

Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a grou...

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Detalles Bibliográficos
Main Authors: Mohseni, Jafar, Zabidi-Hussin, Z.A.M.H., Sasongko, Teguh Haryo
Formato: Artigo
Idioma:Inglês
Publicado: Sociedade Brasileira de Genética 2013
Assuntos:
Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795173/
https://ncbi.nlm.nih.gov/pubmed/24130434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1415-47572013000300001
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