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Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca(2+)-dependent lipid scramblase, its regulation mechanism has remained elusive. Here, we have used cryo-electron microsc...
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| Veröffentlicht in: | eLife |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6414200/ https://ncbi.nlm.nih.gov/pubmed/30785398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44364 |
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