SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism and its hyperactivation is linked to cancer progression. Here we report that Akt undergoes K64 methylation by SETDB1, which is crucial for cell membrane recruitment, phosphorylation and activation of...

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Publicado no:Nat Cell Biol
Main Authors: Wang, Guihua, Long, Jie, Gao, Yuan, Zhang, Weina, Han, Fei, Xu, Chuan, Sun, Li, Yang, Shun-Chin, Lan, Jingqin, Hou, Zhenlin, Cai, Zhen, Jin, Guoxiang, Hsu, Che-Chia, Wang, Yu-Hui, Hu, Junbo, Chen, Tsai-Yu, Li, Hongyu, Lee, Min Gyu, Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414065/
https://ncbi.nlm.nih.gov/pubmed/30692626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0266-1
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