ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway

PURPOSE: Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration in the brain. This study aims to i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Onco Targets Ther
Prif Awduron: Wang, Yanjun, Zhang, Jiachen, Yang, Yihang, Liu, Qian, Xu, Guangming, Zhang, Rui, Pang, Qi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2019
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413739/
https://ncbi.nlm.nih.gov/pubmed/30881039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S195329
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