ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway

PURPOSE: Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration in the brain. This study aims to i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Wang, Yanjun, Zhang, Jiachen, Yang, Yihang, Liu, Qian, Xu, Guangming, Zhang, Rui, Pang, Qi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2019
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413739/
https://ncbi.nlm.nih.gov/pubmed/30881039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S195329
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