Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

Metabotropic glutamate (mGlu) receptors are considered as candidate drug targets for the treatment of schizophrenia. These receptors form a family of eight subtypes (mGlu1 to −8), of which mGlu1 and −5 are coupled to G(q/11), and all other subtypes are coupled to G(i/o). Here, we discuss the possibi...

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Vydáno v:Front Psychiatry
Hlavní autoři: Nicoletti, Ferdinando, Orlando, Rosamaria, Di Menna, Luisa, Cannella, Milena, Notartomaso, Serena, Mascio, Giada, Iacovelli, Luisa, Matrisciano, Francesco, Fazio, Francesco, Caraci, Filippo, Copani, Agata, Battaglia, Giuseppe, Bruno, Valeria
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Psychiatry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413697/
https://ncbi.nlm.nih.gov/pubmed/30890967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2019.00049
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