Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a versatile RNA-binding protein playing a critical role in alternative pre-mRNA splicing regulation in cancer. Emerging data have implicated hnRNP A1 as a central player in a splicing regulatory circuit involving its direct transcriptional...

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Veröffentlicht in:Molecules
Hauptverfasser: Carabet, Lavinia A., Leblanc, Eric, Lallous, Nada, Morin, Helene, Ghaidi, Fariba, Lee, Joseph, Rennie, Paul S., Cherkasov, Artem
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413181/
https://ncbi.nlm.nih.gov/pubmed/30791548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24040763
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