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Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis

Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using experimental and theoretical methods. Their binding to μOR was assessed with radioligand competitive binding assay. A uniform set of binding affinity data contains values for two novel and one previously uncharac...

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Vydáno v:Molecules
Hlavní autoři: Lipiński, Piotr F. J., Kosson, Piotr, Matalińska, Joanna, Roszkowski, Piotr, Czarnocki, Zbigniew, Jarończyk, Małgorzata, Misicka, Aleksandra, Dobrowolski, Jan Cz., Sadlej, Joanna
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412969/
https://ncbi.nlm.nih.gov/pubmed/30791394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24040740
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