A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation

CRISPR-based technology has provided new avenues to interrogate gene function, but difficulties in transgene expression in post-mitotic neurons has delayed incorporation of these tools in the central nervous system (CNS). Here, we demonstrate a highly efficient, neuron-optimized dual lentiviral CRIS...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Savell, Katherine E., Bach, Svitlana V., Zipperly, Morgan E., Revanna, Jasmin S., Goska, Nicholas A., Tuscher, Jennifer J., Duke, Corey G., Sultan, Faraz A., Burke, Julia N., Williams, Derek, Ianov, Lara, Day, Jeremy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
Methods/New Tools
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412672/
https://ncbi.nlm.nih.gov/pubmed/30863790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0495-18.2019
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