A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation

CRISPR-based technology has provided new avenues to interrogate gene function, but difficulties in transgene expression in post-mitotic neurons has delayed incorporation of these tools in the central nervous system (CNS). Here, we demonstrate a highly efficient, neuron-optimized dual lentiviral CRIS...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eNeuro
Egile Nagusiak: Savell, Katherine E., Bach, Svitlana V., Zipperly, Morgan E., Revanna, Jasmin S., Goska, Nicholas A., Tuscher, Jennifer J., Duke, Corey G., Sultan, Faraz A., Burke, Julia N., Williams, Derek, Ianov, Lara, Day, Jeremy J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2019
Gaiak:
Methods/New Tools
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412672/
https://ncbi.nlm.nih.gov/pubmed/30863790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0495-18.2019
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