Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases

Six 1′,5′-anhydrohexitol uridine triphosphates were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of their bases. An improved method for obtaining such 5-substituted hexitol nucleosides and nucleotides is described. The incorporation profile of the nucle...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Renders, Marleen, Dumbre, Shrinivas, Abramov, Mikhail, Kestemont, Donaat, Margamuljana, Lia, Largy, Eric, Cozens, Christopher, Vandenameele, Julie, Pinheiro, Vitor B, Toye, Dominique, Frère, Jean-Marie, Herdewijn, Piet
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Chemical Biology and Nucleic Acid Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412122/
https://ncbi.nlm.nih.gov/pubmed/30698800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz008
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