Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival

Human pluripotent stem cells (hPSCs) are susceptible to numerical and structural chromosomal alterations during long-term culture. We show that mitotic errors occur frequently in hPSCs and that prometaphase arrest leads to very rapid apoptosis in undifferentiated but not in differentiated cells. hPS...

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Pubblicato in:Stem Cell Reports
Autori principali: Zhang, Jing, Hirst, Adam J., Duan, Fuyu, Qiu, Hui, Huang, Rujin, Ji, Ying, Bai, Lufeng, Zhang, Fengzhi, Robinson, Darren, Jones, Mark, Li, Le, Wang, Peizhe, Jiang, Peng, Andrews, Peter W., Barbaric, Ivana, Na, Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411485/
https://ncbi.nlm.nih.gov/pubmed/30773485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.01.013
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