Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival

Human pluripotent stem cells (hPSCs) are susceptible to numerical and structural chromosomal alterations during long-term culture. We show that mitotic errors occur frequently in hPSCs and that prometaphase arrest leads to very rapid apoptosis in undifferentiated but not in differentiated cells. hPS...

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Publicat a:Stem Cell Reports
Autors principals: Zhang, Jing, Hirst, Adam J., Duan, Fuyu, Qiu, Hui, Huang, Rujin, Ji, Ying, Bai, Lufeng, Zhang, Fengzhi, Robinson, Darren, Jones, Mark, Li, Le, Wang, Peizhe, Jiang, Peng, Andrews, Peter W., Barbaric, Ivana, Na, Jie
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411485/
https://ncbi.nlm.nih.gov/pubmed/30773485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.01.013
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