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Amidation Strategy for Final-Step α-Hydroxytropolone Diversification
α-Hydroxytropolones (αHTs) are excellent metalloenzyme-inhibiting fragments that have been the basis for the development of potent inhibitors of various therapeutically important enzymes. The following manuscript describes a final-step amidation approach for αHT diversification. The method takes adv...
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| Udgivet i: | Tetrahedron Lett |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6411066/ https://ncbi.nlm.nih.gov/pubmed/30872871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2018.06.063 |
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