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Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation
Activity-dependent translation requires the transport of mRNAs within membraneless protein assemblies known as neuronal granules from the cell body toward synaptic regions. Translation of mRNA is inhibited in these granules during transport but quickly activated in response to neuronal stimuli at th...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6410804/ https://ncbi.nlm.nih.gov/pubmed/30765518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814385116 |
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