Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

Activity-dependent translation requires the transport of mRNAs within membraneless protein assemblies known as neuronal granules from the cell body toward synaptic regions. Translation of mRNA is inhibited in these granules during transport but quickly activated in response to neuronal stimuli at th...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Tsang, Brian, Arsenault, Jason, Vernon, Robert M., Lin, Hong, Sonenberg, Nahum, Wang, Lu-Yang, Bah, Alaji, Forman-Kay, Julie D.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410804/
https://ncbi.nlm.nih.gov/pubmed/30765518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814385116
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares