26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

Pharmacological agents that raise cAMP and activate protein kinase A (PKA) stimulate 26S proteasome activity, phosphorylation of subunit Rpn6, and intracellular degradation of misfolded proteins. We investigated whether a similar proteasome activation occurs in response to hormones and under various...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: VerPlank, Jordan J. S., Lokireddy, Sudarsanareddy, Zhao, Jinghui, Goldberg, Alfred L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410790/
https://ncbi.nlm.nih.gov/pubmed/30782827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809254116
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