Pivotal role for α(V) integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation

CD4+ follicular helper T cells (Tfh) are essential for germinal center (GC) reactions in the lymph node that generate high-affinity, long-lived plasma cells (LLPCs). Temporal GC analysis suggests B memory cells (Bmem) are generated early, while LLPCs are generated late in the GC reaction. Distinct r...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Schrock, Dillon C., Leddon, Scott A., Hughson, Angela, Miller, Jim, Lacy-Hulbert, Adam, Fowell, Deborah J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410787/
https://ncbi.nlm.nih.gov/pubmed/30770452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809329116
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