Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Usin...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Tam, Hok Hei, Melo, Mariane B., Kang, Myungsun, Pelet, Jeisa M., Ruda, Vera M., Foley, Maria H., Hu, Joyce K., Kumari, Sudha, Crampton, Jordan, Baldeon, Alexis D., Sanders, Rogier W., Moore, John P., Crotty, Shane, Langer, Robert, Anderson, Daniel G., Chakraborty, Arup K., Irvine, Darrell J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086995/
https://ncbi.nlm.nih.gov/pubmed/27702895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606050113
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