Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Usin...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Tam, Hok Hei, Melo, Mariane B., Kang, Myungsun, Pelet, Jeisa M., Ruda, Vera M., Foley, Maria H., Hu, Joyce K., Kumari, Sudha, Crampton, Jordan, Baldeon, Alexis D., Sanders, Rogier W., Moore, John P., Crotty, Shane, Langer, Robert, Anderson, Daniel G., Chakraborty, Arup K., Irvine, Darrell J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086995/
https://ncbi.nlm.nih.gov/pubmed/27702895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606050113
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