Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Usin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Tam, Hok Hei, Melo, Mariane B., Kang, Myungsun, Pelet, Jeisa M., Ruda, Vera M., Foley, Maria H., Hu, Joyce K., Kumari, Sudha, Crampton, Jordan, Baldeon, Alexis D., Sanders, Rogier W., Moore, John P., Crotty, Shane, Langer, Robert, Anderson, Daniel G., Chakraborty, Arup K., Irvine, Darrell J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086995/
https://ncbi.nlm.nih.gov/pubmed/27702895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606050113
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg