Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are characterized by a dense fibrotic stroma, which is considered immunosuppressive in multiple malignancies, but the stromal composition of breast cancer m...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chen, Ivy X., Chauhan, Vikash P., Posada, Jessica, Ng, Mei R., Wu, Michelle W., Adstamongkonkul, Pichet, Huang, Peigen, Lindeman, Neal, Langer, Robert, Jain, Rakesh K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410779/
https://ncbi.nlm.nih.gov/pubmed/30700545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815515116
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