Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are characterized by a dense fibrotic stroma, which is considered immunosuppressive in multiple malignancies, but the stromal composition of breast cancer m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chen, Ivy X., Chauhan, Vikash P., Posada, Jessica, Ng, Mei R., Wu, Michelle W., Adstamongkonkul, Pichet, Huang, Peigen, Lindeman, Neal, Langer, Robert, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410779/
https://ncbi.nlm.nih.gov/pubmed/30700545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815515116
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