Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination in patient-derived neural cultures an...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Neurosci
Main Authors: Sellgren, Carl M., Gracias, Jessica, Watmuff, Bradley, Biag, Jonathan D., Thanos, Jessica M., Whittredge, Paul B., Fu, Ting, Worringer, Kathleen, Brown, Hannah E., Wang, Jennifer, Kaykas, Ajamete, Karmacharya, Rakesh, Goold, Carleton P., Sheridan, Steven D., Perlis, Roy H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410571/
https://ncbi.nlm.nih.gov/pubmed/30718903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0334-7
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker