Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination in patient-derived neural cultures an...

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Publicat a:Nat Neurosci
Autors principals: Sellgren, Carl M., Gracias, Jessica, Watmuff, Bradley, Biag, Jonathan D., Thanos, Jessica M., Whittredge, Paul B., Fu, Ting, Worringer, Kathleen, Brown, Hannah E., Wang, Jennifer, Kaykas, Ajamete, Karmacharya, Rakesh, Goold, Carleton P., Sheridan, Steven D., Perlis, Roy H.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410571/
https://ncbi.nlm.nih.gov/pubmed/30718903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0334-7
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