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CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex
CD40, a member of the TNFR-1 receptor family, shares several features with LMP-1, an oncoprotein encoded by Epstein–Barr virus. CD40 and LMP-1 activate transcription by binding to TRAFs, JAK3 and/or TRADD. CD40’s association with CD40L activates signaling. However, LMP-1 signals independently of a l...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125480/ https://ncbi.nlm.nih.gov/pubmed/11387199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.11.2641 |
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