Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH(2) Core and Evaluation of Their Anticancer Activity

Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH(2)) dendrimers with the simultaneous introduction of lipidic (i-Pr) and cationic (–NH(2)) or anionic (–CO...

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Bibliografiske detaljer
Udgivet i:Pharmaceutics
Main Authors: Seixas, Nalin, Ravanello, Bruno B., Morgan, Ibrahim, Kaluđerović, Goran N., Wessjohann, Ludger A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409784/
https://ncbi.nlm.nih.gov/pubmed/30717083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11020059
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