Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neurons from neuroinflammation-induced degeneration. We demons...

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Published in:Stem Cell Reports
Main Authors: Reinhardt, Lydia, Kordes, Susanne, Reinhardt, Peter, Glatza, Michael, Baumann, Matthias, Drexler, Hannes C.A., Menninger, Sascha, Zischinsky, Gunther, Eickhoff, Jan, Fröb, Claudia, Bhattarai, Prabesh, Arulmozhivarman, Guruchandar, Marrone, Lara, Janosch, Antje, Adachi, Kenjiro, Stehling, Martin, Anderson, Eric N., Abo-Rady, Masin, Bickle, Marc, Pandey, Udai Bhan, Reimer, Michell M., Kizil, Caghan, Schöler, Hans R., Nussbaumer, Peter, Klebl, Bert, Sterneckert, Jared L.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409486/
https://ncbi.nlm.nih.gov/pubmed/30773488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.01.015
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