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Catalytic Asymmetric Synthesis of Trifluoromethylated γ-Amino Acids via Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives

Enabled by the discovery of novel cinchona alkaloid-derived chiral phase-transfer catalysts, highly chemo-, regio-, diastereo- and enantioselective umpolung additions of trifluoromethyl imines to α, β-unsaturated N-acylpyrroles were realized. With a catalyst loading ranging from 0.2 to 5.0 mol%, thi...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Hu, Bin, Deng, Li
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408948/
https://ncbi.nlm.nih.gov/pubmed/29232488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201710915
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