RNA Stabilizes Transcription-Dependent Chromatin Loops Induced By Nuclear Hormones

We show that transcription induced by nuclear receptors for estrogen (E(2)) or retinoic acid (RA) is associated with formation of chromatin loops that juxtapose the 5’ end (containing the promoter) with the enhancer and the 3′ polyA addition site of the target gene. We find three loop configurations...

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Publicado en:Sci Rep
Main Authors: Pezone, Antonio, Zuchegna, Candida, Tramontano, Alfonso, Romano, Antonella, Russo, Giusi, de Rosa, Mariarosaria, Vinciguerra, Maria, Porcellini, Antonio, Gottesman, Max E., Avvedimento, Enrico Vittorio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408484/
https://ncbi.nlm.nih.gov/pubmed/30850627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40123-6
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