DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Russo, Giusi, Landi, Rosaria, Pezone, Antonio, Morano, Annalisa, Zuchegna, Candida, Romano, Antonella, Muller, Mark T., Gottesman, Max E., Porcellini, Antonio, Avvedimento, Enrico V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024116/
https://ncbi.nlm.nih.gov/pubmed/27629060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33222
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