DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chr...

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發表在:Sci Rep
Main Authors: Russo, Giusi, Landi, Rosaria, Pezone, Antonio, Morano, Annalisa, Zuchegna, Candida, Romano, Antonella, Muller, Mark T., Gottesman, Max E., Porcellini, Antonio, Avvedimento, Enrico V.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024116/
https://ncbi.nlm.nih.gov/pubmed/27629060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33222
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