Role of mGlu2 in the 5-HT(2A) receptor-dependent antipsychotic activity of clozapine in mice

BACKGROUND: Serotonin 5-HT(2A) and metabotropic glutamate 2 (mGlu2) are neurotransmitter G protein-coupled receptors (GPCRs) involved in the signaling mechanisms underlying psychosis and schizophrenia treatment. Previous findings in mGlu2 knockout (KO) mice suggested that mGlu2 is necessary for head...

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Publicado en:Psychopharmacology (Berl)
Main Authors: Hideshima, Kelsey S., Hojati, Ashkhan, Saunders, Justin M., On, Doan M., Revenga, Mario de la Fuente, Shin, Jong M., Sánchez-González, Ana, Dunn, Cassandra M., Pais, Alexander B., Pais, Anthony C., Miles, Michael F., Wolstenholme, Jennifer T., González-Maeso, Javier
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408231/
https://ncbi.nlm.nih.gov/pubmed/30209534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-5015-4
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