Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored. Here, we demonstrate that aging impairs the function of mouse fib...

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Publicado en:Cell Stem Cell
Autores principales: Lukjanenko, Laura, Karaz, Sonia, Stuelsatz, Pascal, Gurriaran-Rodriguez, Uxia, Michaud, Joris, Dammone, Gabriele, Sizzano, Federico, Mashinchian, Omid, Ancel, Sara, Migliavacca, Eugenia, Liot, Sophie, Jacot, Guillaume, Metairon, Sylviane, Raymond, Frederic, Descombes, Patrick, Palini, Alessio, Chazaud, Benedicte, Rudnicki, Michael A., Bentzinger, C. Florian, Feige, Jerome N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408230/
https://ncbi.nlm.nih.gov/pubmed/30686765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.12.014
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