mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development

Hepatoblastoma (HB) is the most common pediatric liver malignancy. Around 80% of HB demonstrate simultaneous activation of β-catenin and Yes-associated protein 1 (Yap1). The mechanism by which these signaling pathways contribute to HB pathogenesis remain obscure. Recently, mTORC1 activation was repo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Molina, Laura, Yang, Hong, Adebayo Michael, Adeola O., Oertel, Michael, Bell, Aaron, Singh, Sucha, Chen, Xin, Tao, Junyan, Monga, Satdarshan P.S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407673/
https://ncbi.nlm.nih.gov/pubmed/30863496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26668
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