The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model

Simultaneous mutations in CTNNB1 and activation of c-MET occur in 9%–12.5% of patients with hepatocellular carcinoma (HCC). Coexpression of c-MET-V5 and mutant β-catenin-Myc in mouse liver by sleeping beauty transposon/transposase and hydrodynamic tail vein injection (SB-HTVI) led to the development...

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Vydáno v:Gene Expr
Hlavní autoři: Zhan, Na, Michael, Adeola Adebayo, Wu, Kaiyuan, Zeng, Gang, Bell, Aaron, Tao, Junyan, Monga, Satdarshan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cognizant Communication Corporation 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954626/
https://ncbi.nlm.nih.gov/pubmed/29409568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/105221618X15174108894682
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